【药物名称】T-1815
化学结构式(Chemical Structure):
参考文献No.308999
标题:T-1815
作者:Ozaki, Y.; Sai, H.; Yamada, K.; Onoda, Y.
来源:Drugs Fut 1995,20(8),788
合成路线图解说明:

T-1815 is prepared by the condensation of 2-dimethylamino-2-(2-thienyl)-butanol (I) with 3,4-dimethoxybenzylchloride by means of KOH. Starting compound (I) is obtained as follows: the condensation of the isocyano compound (III) with ethyl chloroformate in the presence of lithium diisopropylamide affords ethyl 2-isocyano-2-(2-thienyl)-butyrate (II), which is then reduced with lithium aluminum hydride, followed by treatment with HCOOH/HCHO to give the amino-alcohol (I).

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