【药物名称】Alkasar-18, NOAC
化学结构式(Chemical Structure):
参考文献No.185439
标题:Treatment of L1210 murine leukemias with liposome-incorporated N4-hexadecyl-1-beta-D-arabinofuranosylcytosine
作者:Schwendener, R.A.; Schott, H.
来源:Int J Cancer 1992,51(3),466-9
合成路线图解说明:

NOAC (II) is prepared from octadecylamine and 4-(1,2,4-triazol-1-yl)-1-beta-D-2',3',5'-tri-O-acetylarabinofuranosyl) pyrimidine-2(1H)-one (I) in dioxane. Yields are > 95%. Purity by HPLC is > 97.5%. Solvent residues (methanol, chloroform) are < 0.3%. NOAC has been analyzed by the following spectroscopic methods: H-1 NMR, C-13 NMR, C-13 DEPT NMR, IR and MS. The spectroscopic data of all methods used is consistent with the structure of NOAC.

参考文献No.280249
标题:Alkasar-18
作者:Schwendener, R.A.; Horber, D.H.; Ottiger, C.; Rentsch, K.; Fiebig, H.H.; Schott, H.
来源:Drugs Fut 1995,20(1),11
合成路线图解说明:

NOAC (II) is prepared from octadecylamine and 4-(1,2,4-triazol-1-yl)-1-beta-D-2',3',5'-tri-O-acetylarabinofuranosyl) pyrimidine-2(1H)-one (I) in dioxane. Yields are > 95%. Purity by HPLC is > 97.5%. Solvent residues (methanol, chloroform) are < 0.3%. NOAC has been analyzed by the following spectroscopic methods: H-1 NMR, C-13 NMR, C-13 DEPT NMR, IR and MS. The spectroscopic data of all methods used is consistent with the structure of NOAC.

参考文献No.282148
标题:Synthesis of 4-alkylcytosine nucleosides and evaluation of cytostatic activity in the L1210 murine leukemia
作者:Schott, H.; H鋟ssler, M.P.; Schwendener, R.A.
来源:Liebigs Ann Chem 1994,5(5),465-70
合成路线图解说明:

NOAC (II) is prepared from octadecylamine and 4-(1,2,4-triazol-1-yl)-1-beta-D-2',3',5'-tri-O-acetylarabinofuranosyl) pyrimidine-2(1H)-one (I) in dioxane. Yields are > 95%. Purity by HPLC is > 97.5%. Solvent residues (methanol, chloroform) are < 0.3%. NOAC has been analyzed by the following spectroscopic methods: H-1 NMR, C-13 NMR, C-13 DEPT NMR, IR and MS. The spectroscopic data of all methods used is consistent with the structure of NOAC.

参考文献No.801412
标题:4-(1,2,4-Triazol-1-yl)-1-beta-D-2',3',5'-tri-O-acetylarabinofuranosyl) pyrimidine-2-(1H)-ones. Valuable intermediates in the synthesis of derivatives of 1-(beta-D-arabinofuranosyl)cytosine (Ara-C)
作者:Divakar, K.J.; Reese, C.B.
来源:J Chem Soc - Perkins Trans I 1982,1171-6
合成路线图解说明:

NOAC (II) is prepared from octadecylamine and 4-(1,2,4-triazol-1-yl)-1-beta-D-2',3',5'-tri-O-acetylarabinofuranosyl) pyrimidine-2(1H)-one (I) in dioxane. Yields are > 95%. Purity by HPLC is > 97.5%. Solvent residues (methanol, chloroform) are < 0.3%. NOAC has been analyzed by the following spectroscopic methods: H-1 NMR, C-13 NMR, C-13 DEPT NMR, IR and MS. The spectroscopic data of all methods used is consistent with the structure of NOAC.

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