Valrocemide, TVP-1901, TV-1901-药物合成数据库

【药物名称】Valrocemide, TVP-1901, TV-1901

化学结构式(Chemical Structure):

参考文献No.	25969
标题:	Derivs. of valproic and 2-valproenoic acid amides and use as anticonvulsants
作者:	Bialer, M.; Hadad, S.; Herzig, J.; Sterling, J.; Lerner, D.; Shirvan, M. (Teva Pharmaceutical Industries Ltd.; Yissum Research Development Co.)
来源:	EP 0659174; JP 1996504831; US 5585358; WO 9501956

合成路线图解说明: The condensation of glycinamide (I) with 2-propylpentanoyl chloride (II) by means of TEA in dichloromethane/water gives the target N-acylated glycinamide.

参考文献No.	685343
标题:	Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine
作者:	Hadad, S.; Bialer, M.
来源:	Pharm Res 1995,12(6),905

合成路线图解说明: The condensation of glycinamide (I) with 2-propylpentanoyl chloride (II) by means of TEA in dichloromethane/water gives the target N-acylated glycinamide.