【药物名称】Elinafide mesilate, LU-79553
化学结构式(Chemical Structure):
参考文献No.26360
标题:New bis-naphthalimides for the treatment of cancer
作者:Keilhauer, G.; Romerdahl, C.; Bra馻, M.F.; Qian, X.-D.; Bousquet, P.; Castellano Berlanga, J.M.; Moran Moset, M.; Perez De Vega, M.J. (BASF AG)
来源:EP 0714387; JP 1997501662; US 5616589; WO 9505365
合成路线图解说明:

By condensation of 1,8-naphthalic anhydride (I) wih N,N?bis(2-aminoethyl)propane-1,2-diamine (II) in refluxing dioxane, or in hot NMM.

参考文献No.56180
标题:Method for producing aromatic bisimides
作者:Koser, S.; Viergutz, W. (BASF AG)
来源:DE 19720803; WO 9852924
合成路线图解说明:

By condensation of 1,8-naphthalic anhydride (I) wih N,N?bis(2-aminoethyl)propane-1,2-diamine (II) in refluxing dioxane, or in hot NMM.

参考文献No.375291
标题:Bis-naphthalimides 3: Synthesis and antitumor activity of N,N'-bis[2-(1,8-naphthalimido)-ethyl]alkanediamines
作者:Bra馻, M.F.; et al.
来源:Anti-Cancer Drug Des 1996,11(4),297
合成路线图解说明:

By condensation of 1,8-naphthalic anhydride (I) wih N,N?bis(2-aminoethyl)propane-1,2-diamine (II) in refluxing dioxane, or in hot NMM.

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