NSC-364432, SarCNU-药物合成数据库

【药物名称】NSC-364432, SarCNU

化学结构式(Chemical Structure):

参考文献No.	56572
标题:	Nitrosourea derivs.
作者:	Suami, T.
来源:	US 4452814

合成路线图解说明: The condensation of N-(2-chloroethyl)-N-nitrosocarbamic acid 4-nitrophenyl ester (I) with sarcosinamide (II) gives the target nitrosourea. Alternatively, the nitrosation of N2-[N-(2-chloroethyl)carbamoyl]sarcosinamide (III) by means of NaNO2 and formic acid also yields the target nitrosourea.

参考文献No.	688728
标题:	(2-Chloroethyl)nitrosourea congeners of amino acid amides
作者:	Suami, T.; Kato, T.; Takino, H.; Hisamatsu, T.
来源:	J Med Chem 1982,25(7),829

合成路线图解说明: The condensation of N-(2-chloroethyl)-N-nitrosocarbamic acid 4-nitrophenyl ester (I) with sarcosinamide (II) gives the target nitrosourea. Alternatively, the nitrosation of N2-[N-(2-chloroethyl)carbamoyl]sarcosinamide (III) by means of NaNO2 and formic acid also yields the target nitrosourea.