【药物名称】Oritavancin, LY-333328
化学结构式(Chemical Structure):
参考文献No.31215
标题:Glycopeptide antibiotic derivs
作者:Cooper, R.D.G.; Huff, B.E.; Nicas, T.I.; Quatroche, J.T.; Rodriguez, M.J.; Snyder, N.J.; Staszak, M.A.; Thompson, R.C.; Wilkie, S.C.; Zweifel, M.J. (Eli Lilly and Company)
来源:EP 0817797; JP 1999502534; WO 9630401
合成路线图解说明:

LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.

参考文献No.35230
标题:Glycopeptide antibiotic derivs
作者:Cooper, R.D.G.; Huff, B.E.; Nicas, T.I.; Quatroche, J.T.; Rodriguez, M.J.; Snyder, N.J.; Staszak, M.A.; Thompson, R.C.; Wilkie, S.C.; Zweifel, M.J. (Eli Lilly and Company)
来源:EP 0667353; EP 1016670; EP 1031576
合成路线图解说明:

LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.

参考文献No.366606
标题:Reductive alkylation of glycopeptide antibiotics: Synthesis and antibacterial activity
作者:Cooper, R.D.G.; Snyder, N.J.; Zweifel, M.J.; Staszak, M.A.; Wilkie, S.C.; Nicas, T.I.; Mullen, D.L.; Butler, T.F.; Rodriguez, M.J.; Huff, B.E.; Thompson, R.C.
来源:J Antibiot 1996,49(6),575-81
合成路线图解说明:

LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.

参考文献No.439603
标题:LY-333328
作者:Fromtling, R.A.; Casta馿r, J.
来源:Drugs Fut 1998,23(1),17
合成路线图解说明:

LY-333328 was synthesized by reductocondensation of the glycopeptide antibiotic A82846B (I) with 4'-chlorobiphenyl-4-carboxaldehyde (II) by means of sodium cyanoborohydride in refluxing methanol.

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