NSC-704057, KOS-953, 17-AAG, CP-127374, NSC-330507D, NSC-330507-药物合成数据库

【药物名称】NSC-704057, KOS-953, 17-AAG, CP-127374, NSC-330507D, NSC-330507

化学结构式(Chemical Structure):

参考文献No.	56601
标题:	Geldanamycin derivs. and antitumor drug
作者:	Inoue, Y.; Sasaki, K. (Kaken Pharmaceutical Co., Ltd.)
来源:	US 4261989

合成路线图解说明: The title compound was prepared by displacement of the 17-methoxy group of geldanamycin (I) with allylamine (II) in chloroform at room temperature.

参考文献No.	452070
标题:	erbB-2 oncogene inhibition by geldanamycin derivatives: Synthesis, mechanism of action, and structure-activity relationships
作者:	Schnur, R.C.; Corman, M.L.; Gallaschun, R.J.; Cooper, B.A.; Dee, M.F.; Doty, J.L.; Muzzi, M.L.; DiOrio, C.I.; Barbacci, E.G.; Miller, P.E.; et al.
来源:	J Med Chem 1995,38(19),3813

合成路线图解说明: The title compound was prepared by displacement of the 17-methoxy group of geldanamycin (I) with allylamine (II) in chloroform at room temperature.