【药物名称】Edotecarin, ED-749, J-107088
化学结构式(Chemical Structure):
参考文献No.561798
标题:Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings
作者:Ohkubo, M.; Nishimura, T.; Honma, T.; Nishimura, I.; Ito, S.; Yoshinari, T.; Suda, H.; Morishima, H.; Nishimura, S.
来源:Bioorg Med Chem Lett 1999,9(23),3307
合成路线图解说明:

The condensation of 6-(benzyloxy)indolylmagnesium bromide (I) with dihalomaleimide (II) afforded the diindolylmaleimide (III), which was oxidatively cyclized to produce indolocarbazole (IV). Glycosylation of (IV) with 1-chloro-tetrabenzylglucose (V) yielded the glycosyl derivative (VI). Subsequent deprotection of the benzyl ethers of (VI) by hydrogenolysis over Pd/C gave (VII). Conversion of the imide function of (VII) to anhydride (VIII) was then effected by treatment with KOH. Finally, coupling of (VIII) with hydrazine (IX) in DMF at 80 C yielded the title compound.

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