BXT-51072-药物合成数据库

【药物名称】BXT-51072

化学结构式(Chemical Structure):

参考文献No.	33155
标题:	Novel cpds. having a benzisoselen-azoline and -azine structure, method for preparating same and therapeutic uses thereof
作者:	Erdelmeier, I.; Chaudiere, J.; Moutet, M.E.; Yadan, J.-C. (Oxis International, Inc.)
来源:	JP 1999501005; US 5968920; WO 9527706

合成路线图解说明: The methylation of 2-(2-bromophenyl)acetonitrile (I) with Me-I and NaH in THF gives 2-(2-bromophenyl)-2-methylpropionitrile (II), which is reduced with BH3/THF to yield 2-(2-bromophenyl)-2-methylpropylamine (III) (1). Finally, this compound is cyclized with potassium selenocyanate in DMF to afford the target 1,2-benzoselenazine.

参考文献No.	604761
标题:	Copper(I)-assisted mild and convenient synthesis of new Se-N heterocycles: Access to a promising class of GPx mimics
作者:	Erdelmeier, I.; Tailhan-Lomont, C.; Yadan, J.C.
来源:	J Org Chem 2000,65(24),8152

合成路线图解说明: The methylation of 2-(2-bromophenyl)acetonitrile (I) with Me-I and NaH in THF gives 2-(2-bromophenyl)-2-methylpropionitrile (II), which is reduced with BH3/THF to yield 2-(2-bromophenyl)-2-methylpropylamine (III) (1). Finally, this compound is cyclized with potassium selenocyanate in DMF to afford the target 1,2-benzoselenazine.