合成路线图解说明: The condensation of 4,6-dichloro-2-methylpyrimidine (I) with 2,4,6-trichloroaniline (II) by means of NaH in THF gives N-(6-chloro-2-methylpyrimidin-4-yl)-N-(2,4,6-trichlorophenyl)amine (III), which is condensed with N-(cyclopropylmethyl)-N-propylamine (IV) by heating at 100-190 C yielding N-(cyclopropylmethyl)-N-[2-methyl-6-(2,4,6-trichlorophenylamino)-pyrimidin-4-yl]-N-propylamine (V). Finally, this compound is chlorinated with N-chlorosuccinimide (NCS) in refluxing chloroform. |