AT-760-药物合成数据库

【药物名称】AT-760

化学结构式(Chemical Structure):

参考文献No.	469677
标题:	The novel cyclopropapyrroloindole (CPI) bisalkylators bearing 3,3'-(1,4-phenylene)diacryloyl group as a linker
作者:	Fukuda, Y.; Seto, S.; Furuta, H.; Ebisu, H.; Oomori, Y.; Terashima, S.
来源:	Bioorg Med Chem Lett 1998,8(15),2003-2004

合成路线图解说明: Deprotection of tert-butoxycarbonyl group of (S)-pyrroloindole (I) by treatment with 3 M HCl in EtOAc afforded amine (II). Then, coupling two equivalents of amine (II) with one equivalent of (phenylene)diacrylic acid (III) in the presence of EDC [N-ethyl-N'-(dimethylaminopropyl)carbodiimide] provided the target bisamide.

参考文献No.	649279
标题:	Novel seco cycloproal[c]pyrrolo [3,2-e]indole bisalkylators bearing a 3,3'-arylenebisacryloylm group as a liker
作者:	Fukuda, Y.; Seto, S.; Furuta, H.; Ebisu, H.; Oomori, Y.; Terashima, S.
来源:	J Med Chem 2001,44(9),1396

合成路线图解说明: Deprotection of tert-butoxycarbonyl group of (S)-pyrroloindole (I) by treatment with 3 M HCl in EtOAc afforded amine (II). Then, coupling two equivalents of amine (II) with one equivalent of (phenylene)diacrylic acid (III) in the presence of EDC [N-ethyl-N'-(dimethylaminopropyl)carbodiimide] provided the target bisamide.