【药物名称】HMR-1402
化学结构式(Chemical Structure):
参考文献No.30985
标题:Substd. benzenesulfonylureas and -thioureas, process for their preparation, their use as medicament or diagnostic agent, as well as medicaments containing them
作者:Englert, H.C.; Gerlach, U.; Mania, D.; G鰃elein, H.; Kaiser, J. (Aventis SA)
来源:DE 19505397; EP 0727416; JP 1996245554; US 5652268
合成路线图解说明:

Amine (I) was converted into amide (III) by condensation with 5-chloro-2-methoxybenzoyl chloride (II). Chlorosulfonation of (III), followed by reaction with ammonia, furnished the corresponding sulfonamide (IV). The required sulfonyl thiourea function was generated by condensation of sulfonamide (IV) with methyl isothiocyanate in the presence of NaH. The title compound was finally isolated as the corresponding sodium salt.

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