-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	32815
标题:	Aryl aliphatic acids
作者:	Johnson, C.R.; Gorins, G.; Honn, K.V.; Marnett, L.J. (Vanderbilt University; Wayne State University)
来源:	US 5238832

合成路线图解说明: The sodium salt prepared from 2-tridecyn-1-ol (I) and sodium hydride in THF was O-alkylated with 4-bromobenzyl bromide to afford ether (II). Then, 2-(carboethoxy)ethylzinc iodide (IV), (obtained from ethyl 3-iodopropanoate (III) and an excess of zinc-copper couple), was condensed with this bromoether (II) in the presence of a triphenylphosphine palladium (0) catalyst in a refluxing mixture of toluene and N,N-dimethyl acetamide. Finally, the resulting 3-(phenyl)propanoic ester (V) was hydrolyzed with NaOH in methanol-water.

参考文献No.	401294
标题:	(Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases
作者:	Gorins, G.; Kuhnert, L.; Johnson, C.R.; Marnett, L.J.
来源:	J Med Chem 1996,39(25),4871

合成路线图解说明: The sodium salt prepared from 2-tridecyn-1-ol (I) and sodium hydride in THF was O-alkylated with 4-bromobenzyl bromide to afford ether (II). Then, 2-(carboethoxy)ethylzinc iodide (IV), (obtained from ethyl 3-iodopropanoate (III) and an excess of zinc-copper couple), was condensed with this bromoether (II) in the presence of a triphenylphosphine palladium (0) catalyst in a refluxing mixture of toluene and N,N-dimethyl acetamide. Finally, the resulting 3-(phenyl)propanoic ester (V) was hydrolyzed with NaOH in methanol-water.