2',4',6'-Trimethoxyacetophenone (I) was condensed with dimethylformamide dimethylacetal (II) in refluxing DMF to afford the enamino ketone (III). Subsequent cyclization of (III) with N1-dicyclopropylmethyl-N1-propyl-guanidine hydrochloride (IV) in the presence of t-BuOK produced the target pyrimidine.