The reaction of cis-4-aminocyclohexylmethanol (I) with di-tert-butyl dicarbonate and triethylamine in methanol gives the corresponding carbamate (II), which is treated with tosyl chloride in pyridine yielding the tosylate (III). The reaction of (III) with tetrabutylammonium fluoride (TBAF) in acetonitrile affords the fluoromethyl derivative (IV), which is deprotected with chlorotrimethylsilane and KI to give 4-(fluoromethyl)cyclohexylamine (V). The reaction of (V) with 1,1'-thiocarbonyl-bis(pyridin-2(1H)-one (SCP) yields the isothiocyanate (VI), which is finally condensed with 4-(1H-imidazol-4-yl)piperidine (VII) by means of diisopropylethylamine (DIEA) in acetonitrile.