【药物名称】L-750667-[125I], [125I]-L-750667, L-750667
化学结构式(Chemical Structure):
参考文献No.24820
标题:Pyrrolo-pyridine derivs.
作者:Baker, R.; Curtis, N.R.; Kulagowski, J.J.; Leeson, P.D.; Ridgill, M.P.; Smith, A.L. (Merck Sharp & Dohme Ltd.)
来源:CA 2116213; EP 0623618; JP 1994279442; US 5432177; US 5622950; WO 9420497
合成路线图解说明:

L-750667 is prepared by condensation between 3-(dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine (I) and 1-(4-iodophenyl)piperazine (II) in refluxing toluene trough a gramine-type substitution of the dimethylamino group.

参考文献No.31586
标题:Pyrrolo-pyridine derivs.
作者:Baker, R.; Kulagowski, J.J.; Curtis, N.R.; Leeson, P.D.; Ridgill, M.P.; Smith, A.L. (Merck Sharp & Dohme Ltd.)
来源:US 5576319
合成路线图解说明:

L-750667 is prepared by condensation between 3-(dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine (I) and 1-(4-iodophenyl)piperazine (II) in refluxing toluene trough a gramine-type substitution of the dimethylamino group.

参考文献No.403918
标题:3-[[4-(4-Chlorophenyl)piperazin-1-yl]-methyl]-1H-pyrrolo[2,3-b]pyridine: An antagonist with high affinity and selectivity for the human dopamine D4 receptor
作者:Kulagowski, J.J.; Broughton, H.B.; Curtis, N.R.; Mawer, I.M.; Ridgill, M.P.; Baker, R.; Emms, F.; Freedman, S.B.; Marwood, R.; Patel, S.; Ragan, C.I.; Leeson, P.D.
来源:J Med Chem 1996,39(10),1941
合成路线图解说明:

L-750667 is prepared by condensation between 3-(dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine (I) and 1-(4-iodophenyl)piperazine (II) in refluxing toluene trough a gramine-type substitution of the dimethylamino group.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us