ISA-13-1-药物合成数据库

【药物名称】ISA-13-1

化学结构式(Chemical Structure):

参考文献No.	555339
标题:	Synthesis and preclinical pharmacology of 2-(2-aminopyrimidino) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1) - A novel biphosphonate
作者:	Cohen, H.; Alferiev, I.S.; Monkkonen, J.; Seibel, M.J.; Pinto, T.; Ezra, A.; Solomon, V.; Stepensky, D.; Sagi, H.; Ornoy, A.; Patlas, N.; Hagele, G.; Hoffman, A.; Breuer, E.; Golomb, G.
来源:	Pharm Res 1999,16(9),1399

合成路线图解说明: The title compound was synthesized by nucleophilic addition of 2-aminopyrimidine (I) to vinylidene-1,1-bisphosphonic acid (II).