【药物名称】
化学结构式(Chemical Structure):
参考文献No.541845
标题:Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: Amino acid derivatives
作者:Nikam, S.S.; Cordon, J.J.; Ortwine, D.F.; Heimbach, T.H.; Blackburn, A.C.; Vartanian, M.G.; Nelson, C.B.; Schwarz, R.D.; Boxer, P.A.; Rafferty, M.F.
来源:J Med Chem 1999,42(12),2266
合成路线图解说明:

Hofmann degradation of tetrahydroisoquinoline (I) with ethyl bromoacetate in the presence of K2CO3 in refluxing acetone produced benzylamine derivative (II). Catalytic hydrogenation of the vinyl and nitro groups of (II) in the presence of Pd/C yielded phenylenediamine (III). This was cyclized with oxalic acid in 2 N HCl at 90 C to afford quinoxalinedione (IV). Finally, nitration of (IV) using KNO3 in cold H2SO4 gave the title compound.

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