WAY-141839, GMA-839, Co-2-6749-药物合成数据库

【药物名称】WAY-141839, GMA-839, Co-2-6749

化学结构式(Chemical Structure):

参考文献No.	45643
标题:	Methods and compsns. for inducing sleep
作者:	Lan, N.T.-Y.; Gee, K.W. (CoCensys, Inc.)
来源:	CA 2163748; WO 9427608

合成路线图解说明: Oxidation of the known 3-alpha-hydroxy-3-beta-trifluoromethyl-5-beta-19-norpregnan-20-one (I) with lead tetraacetate gave the 21-acetoxy derivative (II). Subsequent hydrolysis of the acetate ester group of (II) using K2CO3 in MeOH furnished the desired alcohol along with some 21-methoxy byproduct, which were chromatographically separated.