SIB-1553A-药物合成数据库

【药物名称】SIB-1553A

化学结构式(Chemical Structure):

参考文献No.	33454
标题:	Novel substd. aryl cpds. useful as modulators of acetylcholine receptors
作者:	Vernier, J.M.; McDonald, I.A. (SIBIA Neurosciences, Inc.)
来源:	EP 0874818; JP 2000501080; WO 9719059

合成路线图解说明: The condensation of 4-hydroxythiophenol (I) with 2-(2-chloroethyl)-1-methylpyrrolidine (II) in the presence of K2CO3 in DMF afforded the title thioether, which was isolated as the hydrochloride salt.

参考文献No.	546558
标题:	4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A): A novel cognitive enhance with selectivity for neuronal nicotinic acetylcholine receptors
作者:	Vernier, J.M.; El-Abdellaoul, H.; Holsenback, H.; Cosford, N.D.; Bleicher, L.; Barker, G.; Bontempi, B.; Chavez-Noriega, L.; Menzaghi, F.; Rao, T.S.; Reid, R.; Sacaan, A.I.; Suto, C.; Washburn, M.; Lloyd, G.K.; McDonald, I.A.
来源:	J Med Chem 1999,42(10),1684

合成路线图解说明: The condensation of 4-hydroxythiophenol (I) with 2-(2-chloroethyl)-1-methylpyrrolidine (II) in the presence of K2CO3 in DMF afforded the title thioether, which was isolated as the hydrochloride salt.