OPB-9195-药物合成数据库

【药物名称】OPB-9195

化学结构式(Chemical Structure):

参考文献No.	24649
标题:	Thiazole or imidazole derivs. as Maillard reaction inhibitors
作者:	Yasumura, K.; Miyajima, K.; Nagahama, T.; Ishikawa, S.; Tohyama, Y.; Sugiyama, K. (Otsuka Pharmaceutical Co., Ltd.)
来源:	EP 0638075; JP 1995133264; JP 1998167965; WO 9419335

合成路线图解说明: The title amide was prepared by coupling of the previously reported 5-carboxymethyl-2-isopropylidenehydrazonothiazolidin-4-one (I) with aniline (II) in the presence of EDC and HOBt.