【药物名称】Bimatoprost, AGN-192024, Lumigan
化学结构式(Chemical Structure):
参考文献No.23449
标题:Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivs. as therapeutic agents
作者:Woodward, D.F.; Andrews, S.W.; Burk, R.M.; Garst, M.E. (Allergan, Inc.)
来源:EP 0660716; JP 1996501310; US 5352708; WO 9406433
合成路线图解说明:

The esterification of 17-phenyl-18,19,20-trinorprostaglandin F2alpha (I) with methyl iodide and DBU in acetone gives the corresponding methyl ester (II), which is finally treated with ethylamine in methanol at 80-5 C.

参考文献No.48235
标题:Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivs. as therapeutic agents
作者:Andrews, S.W.; Burk, R.M.; Garst, M.E.; Woodward, D.F. (Allergan, Inc.)
来源:US 5607978
合成路线图解说明:

The esterification of 17-phenyl-18,19,20-trinorprostaglandin F2alpha (I) with methyl iodide and DBU in acetone gives the corresponding methyl ester (II), which is finally treated with ethylamine in methanol at 80-5 C.

参考文献No.621031
标题:Bimatoprost
作者:Rabasseda, X.; Casta馿r, J.; Sorbera, L.A.; Leeson, P.A.
来源:Drugs Fut 2001,26(5),433
合成路线图解说明:

The esterification of 17-phenyl-18,19,20-trinorprostaglandin F2alpha (I) with methyl iodide and DBU in acetone gives the corresponding methyl ester (II), which is finally treated with ethylamine in methanol at 80-5 C.

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