Friedel Crafts acylation of vincamine (I) with acetyl chloride and AlCl3 in dichloromethane yielded a mixture of methyl 10-acetylapovincaminate (II) and smaller amounts of the 11- and 12-acetyl derivatives, which were separated by column chromatography. Then, transesterification of methyl ester (II) with n-hexanol in the presence of HCl afforded the corresponding hexyl ester.