【药物名称】PD-158143
化学结构式(Chemical Structure):
参考文献No.547899
标题:Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers
作者:Schelkun, R.M.; Yuen, P.; Malone, T.C.; Rock, D.M.; Stoehr, S.; Szoke, B.; Tarczy-Hornoch, K.
来源:Bioorg Med Chem Lett 1999,9(16),2447
合成路线图解说明:

The esterification of 4,4-bis(4-hydroxyphenyl)pentanoic acid (I) with diazomethane in ethyl ether/methanol gives the methyl ester (II), which is treated with phenylmagnesium bromide in THF to yield 4,4-bis(4-hydroxyphenyl)-1,1-diphenyl-1-pentanol (III). The reduction of (III) with H2 over Pd/C in methanol affords 4,4-bis(4-hydroxyphenyl)-1,1-diphenylpentane (IV), which is finally condensed with azepane (V) and formaldehyde in hot ethanol/water.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us