Prucalopride, R-093877, R-93877, Resolor-药物合成数据库

【药物名称】Prucalopride, R-093877, R-93877, Resolor

化学结构式(Chemical Structure):

参考文献No.	30131
标题:	Enterokinetic benzamide
作者:	Hendrickx, M.-L.; Van Daele, K.G.C.E.; Van Daele, P.J.V.; Van Daele, G.K.L. (Janssen Pharmaceutica NV)
来源:	EP 0807110; JP 1997512832; US 5854260; WO 9616060

合成路线图解说明: Prucalopride is synthesized by condensation of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid (I) with 1-(3-methoxypropyl)piperidin-4-amine (II) by means of ethyl chloroformate and triethylamine in chloroform.

参考文献No.	489141
标题:	Prucalopride
作者:	Casta馿r, J.; Rabasseda, X.
来源:	Drugs Fut 1999,24(7),729

合成路线图解说明: Prucalopride is synthesized by condensation of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid (I) with 1-(3-methoxypropyl)piperidin-4-amine (II) by means of ethyl chloroformate and triethylamine in chloroform.