S-18841-药物合成数据库

【药物名称】S-18841

化学结构式(Chemical Structure):

参考文献No.	34145
标题:	4-Imidazolidinone cpds.
作者:	Cordi, A.; Lacoste, J.-M.; Millan, M.; Audinot, V. (ADIR et Cie.)
来源:	EP 0780379; US 5677325

合成路线图解说明: Ethyl glycinate (I) was converted to the 2-aminoacetohydroxamic acid (II) by reaction with hydroxylamine in the presence of KOH in aqueous MeOH. Subsequent cyclization of (II) upon treatment with formaldehyde provided the target 3-hydroxyimidazolin-4-one.

参考文献No.	538400
标题:	Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands
作者:	Cordi, A.; Lacoste, J.-M.; Audinot, V.; Millan, M.
来源:	Bioorg Med Chem Lett 1999,9(10),1409

合成路线图解说明: Ethyl glycinate (I) was converted to the 2-aminoacetohydroxamic acid (II) by reaction with hydroxylamine in the presence of KOH in aqueous MeOH. Subsequent cyclization of (II) upon treatment with formaldehyde provided the target 3-hydroxyimidazolin-4-one.