【药物名称】Ro-11-1464
化学结构式(Chemical Structure):
参考文献No.35242
标题:Diazepine derivs.
作者:Hellerbach, J.; Zeller, P.; Binder, D.; Hromatka, O. (F. Hoffmann-La Roche AG)
来源:DE 2405682; GB 1456161; US 4155913
合成路线图解说明:

Treatment of diazepinone (I) with phosphorus pentasulfide in refluxing pyridine affords diazepinethione (II). Subsequent reaction with acetyl hydrazine in refluxing n-butanol gives the intermediate acetylhydrazino compound (III), which on prolonged heating cyclizes to the desired triazolodiazepine.

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