CVT-313-药物合成数据库

【药物名称】CVT-313

化学结构式(Chemical Structure):

参考文献No.	35854
标题:	Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha
作者:	Lum, R.T.; Blum, C.L.; Mackman, R.; Wick, M.M.; Schow, S.R. (CV Therapeutics, Inc.)
来源:	EP 1021186; US 5866702; WO 9805335

合成路线图解说明: The condensation of 2,6-dichloropurine (I) with 4-methoxybenzylamine (II) in butanol at 120 C gives 2-chloro-6-(4-methoxybenzylamino)purine (II), which is treated with isopropyl iodide (IV) and NaH in DMF yielding 2-chloro-9-isopropyl-6-(4-methoxybenzylamino)purine (V). Finally, this compound is condensed with diethanolamine (VI) in DMSO at 160 C.

参考文献No.	436284
标题:	Synthesis and activity of 2,6,9-trisubstituted purines
作者:	Schow, S.R.; et al.
来源:	Bioorg Med Chem Lett 1997,7(21),2697

合成路线图解说明: The condensation of 2,6-dichloropurine (I) with 4-methoxybenzylamine (II) in butanol at 120 C gives 2-chloro-6-(4-methoxybenzylamino)purine (II), which is treated with isopropyl iodide (IV) and NaH in DMF yielding 2-chloro-9-isopropyl-6-(4-methoxybenzylamino)purine (V). Finally, this compound is condensed with diethanolamine (VI) in DMSO at 160 C.