CHS-828-药物合成数据库

【药物名称】CHS-828

化学结构式(Chemical Structure):

参考文献No.	23470
标题:	N-Cyano-N'-pyridylguanidines as serotonin antagonists
作者:	Bramm, E.; Petersen, H.H.J. (Leo Pharmaceutical Products Ltd. A/S)
来源:	EP 0660823; JP 1996501539; US 5563160; US 5696140; WO 9406770

合成路线图解说明: The condensation of pyridin-4-ylamine (I) with the iminodithiocarbonate (II) by means of NaH in DMF gives the isothiourea (III), which is finally condensed with 6-(4-chlorophenoxy)hexylamine (IV) by means of TEA in pyridine. Alternatively, the target guanidine can also be obtained by condensation of N-[6-(4-chlorophenoxy)hexyl]-N'-(4-pyridyl)thiourea (V) with cyanamide by means of DCC and TEA in acetonitrile.

参考文献No.	443698
标题:	Novel cyanoguanidines with potent oral antitumor activity
作者:	Schou, C.; et al.
来源:	Bioorg Med Chem Lett 1997,7(24),3095

合成路线图解说明: The condensation of pyridin-4-ylamine (I) with the iminodithiocarbonate (II) by means of NaH in DMF gives the isothiourea (III), which is finally condensed with 6-(4-chlorophenoxy)hexylamine (IV) by means of TEA in pyridine. Alternatively, the target guanidine can also be obtained by condensation of N-[6-(4-chlorophenoxy)hexyl]-N'-(4-pyridyl)thiourea (V) with cyanamide by means of DCC and TEA in acetonitrile.