-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	35105
标题:	Diarylalkyl cyclic diamine derivs. as chemokine receptor antagonists
作者:	Shiota, T.; Yamagami, S.; Kataoka, K.; Endo, N.; Tanaka, H.; Barnum, D.; Greene, J.; Moree, W.; Ramirez-Weinhouse, M.; Tarby, C. (Teijin Ltd.)
来源:	EP 0914319; JP 1997309877; WO 9744329

合成路线图解说明: Reaction of 3,3-diphenylpropylmethanesulfonate (I) with homopiperazine hydrochloride (II) and NaI in ethanol provides compound (III), which is finally condensed with 4-(methylsulfonyl)benzyl bromide by means of K2CO3 in acetonitrile or by means of NaI in ethanol.

参考文献No.	558193
标题:	Chemokine receptor antagonistic activities and structure-activity relationship of novel homopiperazine derivatives
作者:	Shiota, T.; et al.
来源:	19th Symp Med Chem and 8th Annu Meet Div Med Chem Jpn (Nov 17-19, Tokyo) 1999,Abst 1P-10

合成路线图解说明: Reaction of 3,3-diphenylpropylmethanesulfonate (I) with homopiperazine hydrochloride (II) and NaI in ethanol provides compound (III), which is finally condensed with 4-(methylsulfonyl)benzyl bromide by means of K2CO3 in acetonitrile or by means of NaI in ethanol.