【药物名称】
化学结构式(Chemical Structure):
参考文献No.48019
标题:Substd. benzimidazoles as non-nucleoside inhibitors of reverse transcriptase
作者:Morningstar, M.; Roth, T.; Michejda, C.J. (US Department of Health & Human Services)
来源:WO 0114343
合成路线图解说明:

2-Methyl-6-nitroaniline (I) was acylated with 2,6-difluorobenzoyl chloride (II) to afford the nitroanilide (III). Reduction of the nitro group of (III) with concomitant cyclization using iron powder in refluxing HOAc furnished the benzimidazole (IV). Finally, N-alkylation of (IV) with 2,6-difluoro-alpha-bromotoluene (V) in the presence of NaH provided the title compound.

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