ADAM-II-药物合成数据库

【药物名称】ADAM-II

化学结构式(Chemical Structure):

参考文献No.	40016
标题:	Alkenyldiarylmethane non-nucleoside HIV-1 reverse transcriptase inhibitors
作者:	Rice, W.G.; Casimiro-Garcia, A.; Cushman, M.S. (Purdue Research Foundation; US Department of Health & Human Services)
来源:	WO 9936384

合成路线图解说明: Title compound was prepared by Wittig condensation of benzophenone (I) with the phosphorane derived from (4-methoxycarbonylbutyl)triphenyl phosphonium bromide (II) and sodium hexamethyldisilazide at -78 C.

参考文献No.	560942
标题:	New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors
作者:	Cushman, M.; Casimiro-Garcia, A.; Hejchman, E.; Ruell, J.A..; Huang, M.; Schaeffer, C.A.; Williamson, K.; Rice, W.G.; Buckheit, R.W. Jr.
来源:	J Med Chem 1998,41(12),2076

合成路线图解说明: Title compound was prepared by Wittig condensation of benzophenone (I) with the phosphorane derived from (4-methoxycarbonylbutyl)triphenyl phosphonium bromide (II) and sodium hexamethyldisilazide at -78 C.