BIA-2-024-药物合成数据库

【药物名称】BIA-2-024

化学结构式(Chemical Structure):

参考文献No.	35202
标题:	New derivs. of 10,11-dihydro-10-oxo-5H-dibenz[b, f]azepine-5-carboxamide
作者:	Benes, J.; Soares da Silva, P.M.V.A.; Learmonth, D.A. (Portela & Ca., SA)
来源:	EP 0810216; JP 1998081669; US 5866566; WO 9745416

合成路线图解说明: The title amide has been obtained by reaction of 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide (I) with hydroxylamine in refluxing pyridine.

参考文献No.	625747
标题:	Synthesis, anticonvulsant properties and pharmacokinetic profile of novel 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide derivatives
作者:	Learmonth, D.A.; Benes, J.; Parada, A.; Hainzl, D.; Beliaev, A.; Bonif醕io, M.J.; Matias, P.M.; Carrondo, M.A.; Garrett, J.; Soares-da-Silva, P.
来源:	Eur J Med Chem 2001,36(3),227

合成路线图解说明: The title amide has been obtained by reaction of 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide (I) with hydroxylamine in refluxing pyridine.