PABSA-药物合成数据库

【药物名称】PABSA

化学结构式(Chemical Structure):

参考文献No.	40683
标题:	Preparation method of optically active acyl sulfone amides
作者:	Matsumura, K.; Ishizuka, N. (Shionogi & Co. Ltd.)
来源:	JP 1998045705

合成路线图解说明: Alkylation of 6-methyl-2-propyl-3-pyridinol (I) with bromoester (II) in the presence of K2CO3 afforded the corresponding ether (III). Subsequent hydrolysis of the ester function of (III) by means of NaOH provided carboxylic acid (IV). This was activated by treatment with 1,1'-carbonyldiimidazole and then condensed with 4-isopropylbenzenesulfonamide (V) to produce the target compound.

参考文献No.	544877
标题:	Synthesis and structure-activity relationships of N-[phenyl-(pyridin-3-yl-oxy)acetyl]-benzenesulfonamide derivatives: Novel orally active ETA receptor antagonists
作者:	Yamamori, T.; Hayashi, K.; Konoike, T.; Ishizuka, N.; Kanda, Y.; Matsumura, K.; Mihara, S.; Fujimoto, M.; Sakai, K.
来源:	Symp Med Chem 1997,Abst 1-P-21

合成路线图解说明: Alkylation of 6-methyl-2-propyl-3-pyridinol (I) with bromoester (II) in the presence of K2CO3 afforded the corresponding ether (III). Subsequent hydrolysis of the ester function of (III) by means of NaOH provided carboxylic acid (IV). This was activated by treatment with 1,1'-carbonyldiimidazole and then condensed with 4-isopropylbenzenesulfonamide (V) to produce the target compound.