The condensation of the amine (I) with the chloride of 3(R)-(1-naphthyl)glutaric acid monomethyl ester (II) by means of triethylamine in hot toluene gives the glutaramic ester (III), which is finally hydrolyzed with NaOH in methanol/methylene chloride/water. The intermediates (I) and (II) have been obtained as follows: 1) Intermediate (I) is obtained by condensation of 3,5-dimethylisatoic acid anhydride (IV) with 8-azabicyclo[4.5]decane (V) by means of triethylamine in refluxing toluene. 2) Intermediate (II) is obtained by reaction of 3-(1-naphthyl)glutaric anhydride (VI) with methanol, yielding the racemic monomethyl ester, which without isolation is submitted to optical resolution with cinchonine, thus obtaining the 3(R)-monoester (VII). Finally, this compound is treated with SOCl2 in refluxing ethyl ether.

The condensation of the amine (I) with the chloride of 3(R)-(1-naphthyl)glutaric acid monomethyl ester (II) by means of triethylamine in hot toluene gives the glutaramic ester (III), which is finally hydrolyzed with NaOH in methanol/methylene chloride/water. The intermediates (I) and (II) have been obtained as follows: 1) Intermediate (I) is obtained by condensation of 3,5-dimethylisatoic acid anhydride (IV) with 8-azabicyclo[4.5]decane (V) by means of triethylamine in refluxing toluene. 2) Intermediate (II) is obtained by reaction of 3-(1-naphthyl)glutaric anhydride (VI) with methanol, yielding the racemic monomethyl ester, which without isolation is submitted to optical resolution with cinchonine, thus obtaining the 3(R)-monoester (VII). Finally, this compound is treated with SOCl2 in refluxing ethyl ether.

The condensation of the amine (I) with the chloride of 3(R)-(1-naphthyl)glutaric acid monomethyl ester (II) by means of triethylamine in hot toluene gives the glutaramic ester (III), which is finally hydrolyzed with NaOH in methanol/methylene chloride/water. The intermediates (I) and (II) have been obtained as follows: 1) Intermediate (I) is obtained by condensation of 3,5-dimethylisatoic acid anhydride (IV) with 8-azabicyclo[4.5]decane (V) by means of triethylamine in refluxing toluene. 2) Intermediate (II) is obtained by reaction of 3-(1-naphthyl)glutaric anhydride (VI) with methanol, yielding the racemic monomethyl ester, which without isolation is submitted to optical resolution with cinchonine, thus obtaining the 3(R)-monoester (VII). Finally, this compound is treated with SOCl2 in refluxing ethyl ether.