FR-194921-药物合成数据库

【药物名称】FR-194921

化学结构式(Chemical Structure):

参考文献No.	35646
标题:	Pyrazolopyridine cpd. and pharmaceutical use thereof
作者:	Akahane, A.; Kuroda, S.; Itani, H.; Shimizu, Y. (Fujisawa Pharmaceutical Co., Ltd.)
来源:	EP 0925299; JP 2000514821; US 6124456; WO 9803507

合成路线图解说明: The title compound was synthesized by alkylation of the previously described 6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone (I) with 4-chloro-1-methylpiperidine (II) in the presence of NaH in hot DMF.

合成路线图解说明: An alternative procedure consisted in the Mitsunobu coupling of pyridazinone (I) with 4-hydroxy-1-methylpiperidine (III) in the presence of either diisopropyl- or diethyl azodicarboxylate and triphenylphosphine

参考文献No.	628943
标题:	Design, synthesis and biological evaluation of a novel series of potent, orally active adenosine A1 receptor antagonists with high blood-brain barrier permeability
作者:	Kuroda, S.; Takamura, F.; Tenda, Y.; Itani, H.; Tomishima, Y.; Akahane, A.; Sakane, K.
来源:	Chem Pharm Bull 2001,49(8),988

合成路线图解说明: An alternative procedure consisted in the Mitsunobu coupling of pyridazinone (I) with 4-hydroxy-1-methylpiperidine (III) in the presence of either diisopropyl- or diethyl azodicarboxylate and triphenylphosphine