【药物名称】LF-16.0335
化学结构式(Chemical Structure):
参考文献No.35643
标题:N-Benzenesulphonyl-L-proline derivs. as bradykinin B2 agonists
作者:Dodey, P.; Bondoux, M.; Houziaux, P.; Barth, M.; Ou, K. (Laboratoires Fournier SA)
来源:EP 0925295; US 6071917; WO 9803503
合成路线图解说明:

Title compound was obtained by coupling the sulfonylprolylpiperazine derivative (I) with 4-amidinobenzoic acid (II) in the presence of EDC and HOBt in DMF, followed by conversion to the dihydrochloride salt.

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