【药物名称】
化学结构式(Chemical Structure):
参考文献No.460445
标题:Steroidal and nonsteroidal sulfamates as potent inhibitors of steroid sulfatase
作者:Woo, L.W.C.; Howarth, N,M.; Purohit, A.; Hejaz, H.A.; Reed, M.J.; Potter, B.V.L.
来源:J Med Chem 1998,41(7),1068
合成路线图解说明:

Pechmann condensation of resorcinol (I) with ethyl 2-methylacetylacetate (II) in concentrated sulfuric acid at room temperature provided coumarine (III). Further treatment with one equivalent of sodium hydride and an excess of sulfamoyl chloride yielded the target sulfamate.

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