【药物名称】RP-23618
化学结构式(Chemical Structure):
参考文献No.462746
标题:Identification of a non peptidic RANTES antagonist
作者:Bright, C.; Brown, T.J.; Cox, P.; Halley, F.; Lockey, P.; McLay,, I.M.; Moore, U.; Porter, B.; Williams, R.J.
来源:Bioorg Med Chem Lett 1998,8(7),771-774
合成路线图解说明:

Alkylation of phenothiazine (I) with 1-bromo-3-chloropropane (II) in the presence of NaH in DMF at room temperature afforded chloropropyl compound (III), and then reaction of this compound with 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (IV) and K2CO3 in refluxing dioxan yielded the title compound.

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