VUF-8504-药物合成数据库

【药物名称】VUF-8504

化学结构式(Chemical Structure):

参考文献No.	476311
标题:	A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds
作者:	van Muijlwijk-Koezen, J.E.; Timmerman, H.; Link, R.; van der Goot, H.; Ijzerman, A.P.
来源:	J Med Chem 1998,41(21),3994

合成路线图解说明: The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III), which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.

参考文献No.	485927
标题:	Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides
作者:	de Zwart, M.A.H.; van der Goot, H.; de Zwart, H.; Timmerman, H.
来源:	J Med Chem 1988,31(4),716

合成路线图解说明: The cyclization of 2-methylbenzonitrile (I) with pyridine-2-carbonitrile (II) by means of potassium amide in liquid NH3 gives 3-(2-pyridyl)isoquinoline-1-amine (III), which is finally acylated with 4-methoxybenzoyl chloride (IV) by means of butyllithium in THF.