【药物名称】L-167307
化学结构式(Chemical Structure):
参考文献No.32694
标题:2,5-Substd. aryl pyrroles, comspns. containing suc
作者:De Laszlo, S.E.; Mantlo, N.B.; Ponticello, G.S.; Selnick, H.G.; Liverton, N.J. (Merck & Co., Inc.)
来源:EP 0871444; JP 1999510511; WO 9705878
合成路线图解说明:

The condensation of pyridine-4-carbaldehyde (I) with 4-(methylsulfinyl)acetophenone (II) by means of diethylamine in pyridine gives the chalcone (III), which is treated with 4-fluorobenzaldehyde (IV) and NaCN in DMF to afford the butanedione (V). Finally, this compound is cyclized with ammonium acetate in refluxing acetic acid.

参考文献No.33297
标题:Substd. aryl pyrroles, compsns. containing such cp
作者:De Laszlo, S.E.; Mantlo, N.B. (Merck & Co., Inc.)
来源:WO 9716441
合成路线图解说明:

The condensation of pyridine-4-carbaldehyde (I) with 4-(methylsulfinyl)acetophenone (II) by means of diethylamine in pyridine gives the chalcone (III), which is treated with 4-fluorobenzaldehyde (IV) and NaCN in DMF to afford the butanedione (V). Finally, this compound is cyclized with ammonium acetate in refluxing acetic acid.

参考文献No.477014
标题:Pyrroles and other heterocycles as inhibitors of P
作者:de Laszlo, S.E.; Visco, D.; Agarwal, L.; Chang, L.; Chin, J.; Croft, G.; Forsyth, A.J.; Fletcher, D.S.; Frantz, B.; hacker, C.; Hanlon, W.A.; Harper, C.; Kostura, M.; Li, B.; Luell, S.; MacCoss, M.; mantlo, N.; O'Neill, E.A.; Orevillo, C.; et al.
来源:Bioorg Med Chem Lett 1998,8(19),2689
合成路线图解说明:

The condensation of pyridine-4-carbaldehyde (I) with 4-(methylsulfinyl)acetophenone (II) by means of diethylamine in pyridine gives the chalcone (III), which is treated with 4-fluorobenzaldehyde (IV) and NaCN in DMF to afford the butanedione (V). Finally, this compound is cyclized with ammonium acetate in refluxing acetic acid.

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