【药物名称】NPS-R-467, NPS-467
化学结构式(Chemical Structure):
参考文献No.36762
标题:Calcium receptor active molecules
作者:Nemeth, E.F.; Van Wagenen, B.C.; Balandrin, M.F. (NPS Pharmaceuticals, Inc.)
来源:WO 9304373
合成路线图解说明:

Title compound was prepared by reductive alkylation of 3-phenylpropylamine (I) with 3'-methoxyacetophenone (II) using NaCNBH3 in the presence of titanium isopropoxide in EtOH. Subsequent chiral resolution of the resulting secondary amine (III) by chromatography on ChiralCel OD provided the desired R-enantiomer.

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