Coupling of isovanillin (I) with 3-hydroxytetrahyrofuran (II) in the presence of triphenyl phosphine and diisopropyl azodicarboxylate yielded the tetrahydrofuryl ether (III). Subsequent oxidation of the aldehyde using sodium chlorite and sulfamic acid gave carboxylic acid (IV), which was further converted to acid chloride (V) upon treatment with SOCl2 in toluene. Finally, condensation of (V) with 4-amino-3,5-dimethylisoxazole (VI) provided the title compound.