Cystazosin-药物合成数据库

【药物名称】Cystazosin

化学结构式(Chemical Structure):

参考文献No.	474200
标题:	Search for alpha1-adrenoceptor subtypes selective antagonists: Design, synthesis and biological activity of cystazosin, an alpha1D-adrenoceptor antagonist
作者:	Minarini, A.; Budriesi, R.; Chiarini, A.; Leonardi, A.; Melchiorre, C.
来源:	Bioorg Med Chem Lett 1998,8(11),1353

合成路线图解说明: The monoacylation of disulfide (I) with 2-furylcarbonyl chloride (II) by means of 48% HBr in ethanol/water at 80 C gives the monoamide (III), which is then condensed with 2-chloro-6,7-dimethoxyquinazoline-4-amine (IV) in refluxing isoamyl alcohol.

合成路线图解说明: Cystamine (I) was acylated with 2-furoyl chloride (II) in the presence of a catalytic amount of HBr to give amide (III). This was then condensed with chloroquinazoline (IV) in refluxing isoamyl alcohol to yield the title compound.