-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	574792
标题:	Antitumor polycyclic acridines.7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines
作者:	Stanslas, J.; Hagan, D.J.; Ellis, M.J.; Turner, C.; Carmichael, J.; Ward, W.; Hammonds, T.R.; Stevens, M.F.G.
来源:	J Med Chem 2000,43(8),1563

合成路线图解说明: Treatment of 9-chloroacridine (I) with NaN3 in aqueous acetone affords azidoacridine (II), which is submitted to a cycloaddition reaction with 5-chloro-1-pentynyl (III) to yield 9-(triazol-1-yl)acridine (IV). Finally, (IV) is cyclized by thermolysis in hot diphenyl ether.