【药物名称】MEN-11066
化学结构式(Chemical Structure):
参考文献No.7782
标题:New (benzofuran-2-yl)imidazoles having pharmaceutically activity, their salts and relevant production processes
作者:Pestellini, V.; Ghelardoni, M.; Giannotti, D.; Giolitti, A.; Barzanti, A.; Ciappi, R.; Ortolani, C. (Menarini Industrie Farma Riunite Srl)
来源:EP 0257171; JP 1988072687; US 4800208
合成路线图解说明:

Methanol derivative (I) is converted into the corresponding methyl chloride compound (II) by reaction with thionyl chloride in dichloromethane/cyclohexane. The desired product is then obtained by displacement of the chlorine by attack with 1H-1,2,4-triazole (III) in dioxane.

参考文献No.36498
标题:Heterocyclic furan cpds., their preparation and use as aromatase inhibitors
作者:Lombardi, P.; Di Pietro, G. (Menarini Industrie Farma Riunite Srl)
来源:WO 9818791
合成路线图解说明:

Methanol derivative (I) is converted into the corresponding methyl chloride compound (II) by reaction with thionyl chloride in dichloromethane/cyclohexane. The desired product is then obtained by displacement of the chlorine by attack with 1H-1,2,4-triazole (III) in dioxane.

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