Amelubant, BIIL-284-药物合成数据库

【药物名称】Amelubant, BIIL-284

化学结构式(Chemical Structure):

参考文献No.	29170
标题:	Substd. benzamidines, their production and their use as medicaments
作者:	Anderskewitz, R.; Schromm, K.; Renth, E.-O.; Birke, F.; F黦ner, A.; Heuer, H.; Meade, C. (Boehringer Ingelheim GmbH)
来源:	DE 4424713; EP 0770059; JP 1998502645; US 5731332; WO 9602497

合成路线图解说明: Nitrile (I) was converted to hydroxamic acid (II) upon treatment with hydroxylamine. Further hydrogenation in the presence of Raney-nickel provided amidine (III), which was finally condensed with ethyl chloroformate to yield the title compound.

合成路线图解说明: Nitrile (I) was converted to hydroxamic acid (II) upon treatment with hydroxylamine. Further hydrogenation in the presence of Raney-nickel provided the target amidine.