【药物名称】
化学结构式(Chemical Structure):
参考文献No.478101
标题:Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives as a potential gstric H+/K+-ATPase inhibitor
作者:Yoon, S.-H.; Seo, S.; Lee, Y.; Hwang, S.; Kim, D.Y.
来源:Bioorg Med Chem Lett 1998,8(14),1909
合成路线图解说明:

Reaction of chloromethylpyridine (I) with NaOH in aqueous THF afforded alcohol (II), which was oxidized to formylpyridine (III) with selenium dioxide in refluxing pyridine. Subsequent condensation of aldehyde (III) with phosphorane (IV) in THF provided enone (V), and this was hydrogenated in the presence of Pd/C in MeOH to give (VI). Finally, condensation of ketone (VI) with aminothiophenol (VII) in the presence of p-toluenesulfonic acid in refluxing benzene yielded the corresponding benzothiazolidine.

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