【药物名称】Centbucridine, CDRI-64/124
化学结构式(Chemical Structure):
参考文献No.608291
标题:Compounds acting on the central nervous system. IV. 4-substituted 2,3-polymethylenequinolines
作者:Patnaik, G.K.; Vohra, M.M.; Bindra, J.S.; Garg, C.P.; Anand, N.
来源:J Med Chem 1966,9(4),483
合成路线图解说明:

Anthranitic acid (I) is reacted with cyclohexanone (II) to give 5-hydroxy-1,2,3,4-tetrahydroacridine (III). The hydroxy compound (III) is then reacted with phosphorous oxychloride to give 5-chloro-1,2,3,4-tetrahydroacridine (IV). Aminolysis of (IV) with n-butylamine affords centbucridine.

参考文献No.701394
标题:Studies in 4-substituted 2,3-polymethylene quinolines
作者:Patnaik, G.K.; et al.
来源:CNS Drugs Ed. G.S. Sidhu, CSI, New Delhi
合成路线图解说明:

Anthranitic acid (I) is reacted with cyclohexanone (II) to give 5-hydroxy-1,2,3,4-tetrahydroacridine (III). The hydroxy compound (III) is then reacted with phosphorous oxychloride to give 5-chloro-1,2,3,4-tetrahydroacridine (IV). Aminolysis of (IV) with n-butylamine affords centbucridine.

参考文献No.800483
标题:Centbucridine
作者:Arya, V.P.
来源:Drugs Fut 1980,5(6),281
合成路线图解说明:

Anthranitic acid (I) is reacted with cyclohexanone (II) to give 5-hydroxy-1,2,3,4-tetrahydroacridine (III). The hydroxy compound (III) is then reacted with phosphorous oxychloride to give 5-chloro-1,2,3,4-tetrahydroacridine (IV). Aminolysis of (IV) with n-butylamine affords centbucridine.

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