PD-165167-药物合成数据库

【药物名称】PD-165167

化学结构式(Chemical Structure):

参考文献No.	476980
标题:	Design, synthesis, and evaluation of coumarins as potent and selective dopamine D4 antagonists
作者:	Kesten, S.R.; et al.
来源:	216th ACS Natl Meet (Aug. 23-27, Boston) 1998,Abst MEDI 123

合成路线图解说明: Photochemical bromination of 7-methylcoumarin (I) using N-bromosuccinimide and azobis(isobutyronitrile) provided the benzylic bromide (II). N-Phenyl ethylenediamine (V) was prepared by reaction between aniline (III) and oxazolidone (IV) at 140 C. Then, alkylation of amine (V) with bromide (II) in the presence of K2CO3 in refluxing acetonitrile provided the title compound.

参考文献No.	548645
标题:	Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists
作者:	Kesten, S.R.; Heffner, T.G.; Johnson, S.J.; Pugsley, T.A.; Wright, J.L.; Wise, L.D.
来源:	J Med Chem 1999,42(18),3718

合成路线图解说明: Photochemical bromination of 7-methylcoumarin (I) using N-bromosuccinimide and azobis(isobutyronitrile) provided the benzylic bromide (II). N-Phenyl ethylenediamine (V) was prepared by reaction between aniline (III) and oxazolidone (IV) at 140 C. Then, alkylation of amine (V) with bromide (II) in the presence of K2CO3 in refluxing acetonitrile provided the title compound.